Pepa richangoburwa rakaburitswa muJournal yePhysiology yakadzamisa nyaya yehudiki-kusimudzira mhedzisiro yekurovedza muviri pazvipenyu zvinochembera, kuvaka pabasa rekare rakaitwa nembeva dzema lab pedyo nekupera kwehupenyu hwavo hwechisikigo hwaikwanisa kuwana vhiri remaekisesaizi.
Pepa rakanyatsotsanangurwa, "A molecular siginecha inotsanangura kurovedza muviri nekuchembera uye in vivo partial reprogramming in skeletal muscle," inodonongodza vanyori gumi nevatanhatu vanobatana, vatanhatu vavo vanobatana neU yeA. Munyori anowirirana ndiKevin Murach, mutevedzeri wapurofesa muU of A's Department of Health, Human Performance and Recreation, uye munyori wekutanga ndiRonald G. Jones III, Ph.D.mudzidzi muMurach's Molecular Muscle Mass Regulation Laboratory.
Kune iri bepa, vaongorori vakafananidza mbeva dzekuchembera dzaikwanisa kuwana huremu hwekuita vhiri nemakonzo akange aitwa epigenetic reprogramming kuburikidza nekutaura kweYamanaka zvinhu.
Zvinhu zveYamanaka zvinhu zvina zveprotein transcription factor (inozivikanwa seOct3/4, Sox2, Klf4 uye c-Myc, inowanzopfupikiswa kuOKSM) inogona kudzoreredza maseru akatsanangurwa zvakanyanya (sesero reganda) kudzokera ku stem cell, inova hudiki uye hunochinja-chinja mamiriro.Mubairo weNobel muPhysiology kana Medicine wakapihwa Dr. Shinya Yamanaka nekuda kwekuwanikwa uku muna 2012. Mumiyedzo chaiyo, kupinza maYamanaka zvinhu mumuviri wese mumakonzo kunogona kunatsiridza zviratidzo zvekuchembera nekutevedzera kuchinjika kunowanzo kune vechidiki vakawanda. masero.
Pazvinhu zvina, Myc inokonzereswa nekurovedza skeletal tsandanyama.Myc inogona kushanda sechisikigo inokonzeresa reprogramming kukurudzira mumhasuru, zvichiita kuti ive pfungwa inobatsira yekufananidza pakati pemasero akagadziridzwa kuburikidza nepamusoro pekutaura kweYamanaka zvinhu uye masero akagadziridzwa kuburikidza nekuita maekisesaizi - "reprogramming" mune yekupedzisira nyaya inoratidza maitiro. kukurudzira kwezvakatipoteredza kunogona kushandura kuwanikwa uye kutaura kwemajini.
Vatsvakurudzi vakafananidza skeletal tsandanyama yemakonzo akanga abvumirwa kurovedza muviri kwenguva refu muupenyu kune skeletal tsandanyama yemakonzo yakanyanyisa OKSM mumhasuru dzadzo, pamwe chete nemakonzo akagadziridzwa akaganhurirwa kune kuwandisa kweMyc chete mumhasuru dzadzo.
Pakupedzisira, boka racho rakasarudza kuti kurovedza muviri kunosimudzira chimiro che molecular inowirirana ne epigenetic partial programming.Kureva kuti: kurovedza muviri kunogona kutevedzera zvikamu zvema molecular profile of muscles zvakaratidzwa kune Yamanaka factor (nekudaro kuratidza ma molecular maitiro emamwe masero evechidiki).Izvi zvinobatsira zvekurovedza muviri zvinogona muchikamu kuverengerwa kune chaiwo zviito zveMyc mumhasuru.
Kunyange zvingava nyore kufungidzira kuti rimwe zuva tingazokwanisa kushandisa Myc mumhasuru kuti tiwane mhedzisiro yekurovedza muviri, nokudaro tichidzivirira isu basa rakaoma chairo, Murach anoyambira kuti ingave mhedzisiro isiriyo yekutora.
Chekutanga, Myc haaizokwanisa kudzokorodza ese akadzika mhedzisiro maitiro ane muviri wese.Ndiko zvakare honzeri yemamota negomarara, saka kune njodzi dzinowanikwa pakugadzirisa kutaura kwayo.Pane kudaro, Murach anofunga kuti kushandisa Myc kunogona kushandiswa zvakanyanya senzira yekuedza kuti unzwisise nzira yekudzoreredza kujairana nemamhasuru ekare anoratidza kuderera kwekudaira.Pamwe inogona zvakare kuve nzira yekukwirisa mhinduro yevazivi vemuchadenga mune zero giravhiti kana vanhu vakavharirwa pakuzorora pamubhedha vanongove nekwaniso shoma yekurovedza muviri.Myc ine zvakawanda zvinokonzeresa, zvese zvakanaka nezvakaipa, saka kutsanangura izvo zvinobatsira zvinogona kutungamira kune yakachengeteka kurapa iyo inogona kushanda kune vanhu munzira.
Murach anoona tsvakiridzo yavo sekuwedzera kusimbiswa kwekurovedza muviri sepolypill."Kuekisesaiza ndiwo mushonga une simba watinawo," anodaro, uye unofanirwa kutorwa sehutano hunosimudzira - uye hunogona kuwedzera hupenyu - kurapwa pamwe nemishonga uye kudya kune hutano.
Murach naJones vanyori paU yeA vaisanganisira purofesa wesainzi Nicholas Greene, pamwe nevanopa vaongorori Francielly Morena Da Silva, Seongkyun Lim naSabin Khadgi.
Nguva yekutumira: Mar-02-2023